https://wiki.genometracker.org/w/Special:RecentChanges Track the most recent changes to the wiki in this feed. en MediaWiki 1.39.2 Wed, 17 Jun 2026 02:33:23 GMT https://wiki.genometracker.org/index.php?title=Monte_Carlo_Club&diff=6689&oldid=6686 https://wiki.genometracker.org/index.php?title=Monte_Carlo_Club&diff=6689&oldid=6686 <p><span dir="auto"><span class="autocomment">Papers found by Hui</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:24, 16 June 2026</td> </tr><tr><td colspan="4" class="diff-multi" lang="en">(2 intermediate revisions by the same user not shown)</td></tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l21">Line 21:</td> <td colspan="2" class="diff-lineno">Line 21:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Tick genomics &amp; native immunity==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Tick genomics &amp; native immunity==</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">===Papers found by Hui===</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* Abbas, M. N., Jmel, M. A., Mekki, I., Dijkgraaf, I., &amp; Kotsyfakis, M. (2023). Recent Advances in Tick Antigen Discovery and Anti-Tick Vaccine Development. International journal of molecular sciences, 24(5), 4969. https://doi.org/10.3390/ijms24054969. I found this review article to be the most complete and well-rounded one. It summarizes recent progress in anti-tick vaccine development, especially antigen-based strategies that target tick feeding, reproduction, attachment, and pathogen transmission. The authors also explain how modern approaches such as genomics, transcriptomics, proteomics, and reverse vaccinology have helped identify new vaccine candidates from tick tissues including the salivary glands, midgut, eggs, Malpighian tubules, and cement. The review covers several major antigens and vaccine targets, including Bm86/Bm95, ferritin, aquaporins, subolesin, Salp15, metalloproteases, serpins, and the recent 19ISP mRNA vaccine targeting Ixodes scapularis salivary proteins.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* Allen J.R., Humphreys S.J. Immunisation of guinea pigs and cattle against ticks. Nature. 1979;280:491–493. doi: 10.1038/280491a0. https://www-nature-com.proxy.wexler.hunter.cuny.edu/articles/280491a0. The first review article referred to this early study, so I thought it was important to include. This paper is an early proof-of-concept showing that hosts can be immunized against ticks using antigens extracted from the internal organs of partially fed ticks, especially the midgut and reproductive organs. It helped establish the idea that internal tick antigens, not only salivary proteins, could be useful vaccine targets.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* Hart, T. M., Cui, Y., Telford, S. R., Marín-López, A., Calloway, K., Dai, Y., Matias, J., DePonte, K., Jaycox, J., DeBlasio, M., Hoornstra, D., Belperron, A. A., Cibichakravarthy, B., Johnson, E. E., Alameh, M. G., Dwivedi, G., Hovius, J. W. R., Bockenstedt, L. K., Weissman, D., Ring, A. M., … Fikrig, E. (2025). Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans. Science translational medicine, 17(791), eads9207. https://doi.org/10.1126/scitranslmed.ads9207. This paper developed a high-throughput yeast display platform called IscREAM, which can screen antibody responses against more than 3,000 predicted extracellular proteins from Ixodes scapularis. Using vaccinated guinea pigs, Lyme disease patients, and a naturally tick-resistant individual, the authors identified 199 immunogenic tick antigens. They also showed that both salivary and cement proteins may contribute to acquired tick resistance.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* Narasimhan, Sukanya et al. “Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission.” PloS one vol. 2,5 e451. 16 May. 2007, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0000451. This article focuses on early Ixodes scapularis salivary proteins that are important for tick feeding and Borrelia burgdorferi transmission. The authors show that the tick salivary gland transcriptome and proteome change during feeding, especially between the first 24 hours of attachment and later feeding stages. Importantly, they found that guinea pigs repeatedly exposed only to the first 24 hours of tick feeding developed acquired tick immunity, shown by inflammation at the bite site, rapid tick rejection, reduced engorgement, and impaired Borrelia transmission.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">===Tick genomics===</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Mini-review: [https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2018.00176/full Kitsou &amp; Pal (2018).] Ixodes immune responses against Lyme disease pathogens. Font Cell Infect Microb.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Mini-review: [https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2018.00176/full Kitsou &amp; Pal (2018).] Ixodes immune responses against Lyme disease pathogens. Font Cell Infect Microb.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* The IMD pathway: [https://journals.asm.org/doi/10.1128/mbio.00703-22 Sidak-Loftis et al (2022)]; mBio</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* The IMD pathway: [https://journals.asm.org/doi/10.1128/mbio.00703-22 Sidak-Loftis et al (2022)]; mBio</div></td></tr> <!-- diff cache key my_wiki:diff::1.12:old-6686:rev-6689 --> </table> Tue, 16 Jun 2026 17:24:04 GMT Wikiuser https://wiki.genometracker.org/w/Talk:Monte_Carlo_Club