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[[File: | [[File:Protrait-July-2024-Qiu.jpg| x250 px | thumb]] | ||
| <center> <strong>Welcome to Qiu Lab Wiki @ Hunter</strong><br>Weigang Qiu, Ph.D., Professor<br> [http://biology.hunter.cuny.edu Department of Biological Sciences]<br> | | <center> <strong>Welcome to Qiu Lab Wiki @ Hunter</strong><br>Weigang Qiu, Ph.D., Professor<br> [http://biology.hunter.cuny.edu Department of Biological Sciences]<br> | ||
[https://hunter.cuny.edu Hunter College] of<br> [https://www.cuny.edu City University of New York]<br> Belfer Research Building, Room 402<br>413 East 69th Street, New York, NY 10021<br>Office: 1-212-896-0445<br>Email: wqiu-at-(hunter.cuny.edu)<br> </center> | [https://hunter.cuny.edu Hunter College] of<br> [https://www.cuny.edu City University of New York]<br> Belfer Research Building, Room 402<br>413 East 69th Street, New York, NY 10021<br>Office: 1-212-896-0445<br>Email: wqiu-at-(hunter.cuny.edu)<br> </center> | ||
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===Lyme Genomics, Evolution, & Ecology=== | ===Lyme Genomics, Evolution, & Ecology=== | ||
<gallery mode="packed" heights="200px" perrow="4" style="text-align:left"> | <gallery mode="packed" heights="200px" perrow="4" style="text-align:left"> | ||
File:Screenshot_2024-08-15_094908.png | link=https://journals.asm.org/doi/10.1128/mbio.01749-24 | Akther et al. 2024. "Natural selection and recombination at host-interacting lipoprotein loci drive genome diversification of Lyme disease and related bacteria" '''''mBio''''' 0:e01749-24. Press coverage: [https://www.gc.cuny.edu/news/cuny-graduate-center-biologists-map-dna-lyme-disease-bacteria CUNY Graduate Center News Story]; [https://hunter.cuny.edu/news/hunter-researcher-maps-dna-of-lyme-disease-bacteria/ Hunter press] | |||
File:Applsci-13-11587-g004.png | link=https://doi.org/10.3390/app132011587 | Di, Chong, Brian Sulkow, Weigang Qiu, and Shipeng Sun. 2023. "Effects of Micro-Scale Environmental Factors on the Quantity of Questing Black-Legged Ticks in Suburban New York" '''''Applied Sciences''''' 13, no. 20: 11587. | File:Applsci-13-11587-g004.png | link=https://doi.org/10.3390/app132011587 | Di, Chong, Brian Sulkow, Weigang Qiu, and Shipeng Sun. 2023. "Effects of Micro-Scale Environmental Factors on the Quantity of Questing Black-Legged Ticks in Suburban New York" '''''Applied Sciences''''' 13, no. 20: 11587. | ||
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(Fall 2022, Spring 2023 & Summer 2023) | (Fall 2022, Spring 2023 & Summer 2023) | ||
|| | || | ||
* Brandon Ely: CUNY Grad Center, Biology/MCD doctoral program | * Brandon Ely: CUNY Grad Center, Biology/MCD doctoral program | ||
* Dr Yozen Hernandez: System administrator (part-time), Ph.D. from Boston University | * Dr Yozen Hernandez: System administrator (part-time), Ph.D. from Boston University | ||
|| | || | ||
* Tasmina Hassan: Hunter Bio/CS | * Tasmina Hassan: Hunter Bio/CS | ||
Line 67: | Line 68: | ||
* Tara Doma Lama: Hunter Bio/Bioinformatics | * Tara Doma Lama: Hunter Bio/Bioinformatics | ||
* Hagar Abuzaid: Hunter Bio | * Hagar Abuzaid: Hunter Bio | ||
|- | |- | ||
| Alumni (Since Fall 2002) | | Alumni (Since Fall 2002) | ||
|| | || | ||
* Dr Lia Di: Ph.D. from Nanjing Agricultural University & Wisconsin Blood Institute | * Li Li (Lily, 2023): CUNY Grad Center, Biology/EEB doctoral program | ||
* Dr Lia Di: Ph.D. Postdoctoral Research Associate, from Nanjing Agricultural University & Wisconsin Blood Institute | |||
* Dr Saymon Akther (2022): CUNY Grad Center, Biology/EEB | * Dr Saymon Akther (2022): CUNY Grad Center, Biology/EEB | ||
* Dr Rayees Rahman: Hunter Bio/Bioinformatics, Ph.D. from Mt Sinai Medical School | * Dr Rayees Rahman: Hunter Bio/Bioinformatics, Ph.D. from Mt Sinai Medical School | ||
Line 81: | Line 82: | ||
* Dr Vincent Xue: CUNY CS/Bioinformatics, Ph.D. from MIT | * Dr Vincent Xue: CUNY CS/Bioinformatics, Ph.D. from MIT | ||
* Dr Fubin Li: CUNY Grad Center, Biology/MCD (Dr Laurel Eckhardt) | * Dr Fubin Li: CUNY Grad Center, Biology/MCD (Dr Laurel Eckhardt) | ||
* Dr Oliver Attie: Postdoctoral Research Associate, Ph.D. from NYU | |||
|| | || | ||
(published coauthors)<br> | (published coauthors)<br> | ||
Line 104: | Line 106: | ||
==Web Apps== | ==Web Apps== | ||
===Apps with Collaborators=== | ===Apps with Collaborators (or from published papers)=== | ||
<gallery mode="packed" heights="200px" perrow="4" style="text-align:left"> | <gallery mode="packed" heights="200px" perrow="4" style="text-align:left"> | ||
File:Screenshot_2024-06-19_205621.png | link=https://cov.genometracker.org/finalelisa-app/ | Borrelia diagnostic antigens (App developed by Liann Aris-Henry; Data from [https://journals.asm.org/doi/10.1128/jcm.01142-19 Arumugam et al (2019)]) | |||
File:Screenshot_2024-06-18_144931.png | link=https://cov.genometracker.org/borrelia-app/ | Borrelia growth transcriptome (App developed by Laziz Asamov; Data from [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164165 Arnold et al (2016)]) | |||
File: Silac.png | link=http://borreliabase.org/~wgqiu/Polotskaia_etal_2014/supp-fig-s1/ | Data & [http://borreliabase.org/~wgqiu/Polotskaia_etal_2014/supp-table-s1/ GSEA] associated with Polotskaia_etal_2014 (with Bargonetti Lab @Hunter) | File: Silac.png | link=http://borreliabase.org/~wgqiu/Polotskaia_etal_2014/supp-fig-s1/ | Data & [http://borreliabase.org/~wgqiu/Polotskaia_etal_2014/supp-table-s1/ GSEA] associated with Polotskaia_etal_2014 (with Bargonetti Lab @Hunter) | ||
File:Screenshot_2023-03-24_122016.png | link=http://borreliabase.org/~wgqiu/clickme-khalikuz/temp-Points.html | Phosphoproteome MDM2KD data set (with Bargonetti Lab @Hunter) | File:Screenshot_2023-03-24_122016.png | link=http://borreliabase.org/~wgqiu/clickme-khalikuz/temp-Points.html | Phosphoproteome MDM2KD data set (with Bargonetti Lab @Hunter) | ||
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</gallery> | </gallery> | ||
== | ==Curricular Development & Bioinformatics/QuBi Advising== | ||
* QuBi advisors: Weigang Qiu, Ntino Krampis, Rabindra Mandal (Biology); Saad Mneimeih, Lei Xie (CS); Akira Kawamura (Chem); Dana Sylvan (Math & Stats) | * QuBi advisors: Weigang Qiu, Ntino Krampis, Rabindra Mandal (Biology); Saad Mneimeih, Lei Xie (CS); Akira Kawamura (Chem); Dana Sylvan (Math & Stats) | ||
* | ** Permission for non-Biology majors to take BIOL203 & BIOL425, every Spring | ||
** Collect names, major, and IDs to send to course coordinator to grant permission. Waive BIOL10200 pre-reqs for taking BIOL203. | |||
* Curricular resources: | |||
** [http://biology.hunter.cuny.edu/index.php?option=com_content&view=article&id=66&Itemid=73 Biology courses and pre-reqs] | |||
** [https://hunter-undergraduate.catalog.cuny.edu/programs/BIO1-BA Hunter Biology Major 1 (including the Bioinformatics Option)] | |||
** [https://hunter-undergraduate.catalog.cuny.edu/programs/CHEM2-BA Hunter Chemistry Major 2 (including the Bioinformatics Option)] | ** [https://hunter-undergraduate.catalog.cuny.edu/programs/CHEM2-BA Hunter Chemistry Major 2 (including the Bioinformatics Option)] | ||
** [https://hunter-undergraduate.catalog.cuny.edu/programs/COMPSCI-BA Hunter Computer Science (including Bioinformatics Concentration)] | ** [https://hunter-undergraduate.catalog.cuny.edu/programs/COMPSCI-BA Hunter Computer Science (including Bioinformatics Concentration)] | ||
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** Declaration of Bioinformatics concentration: In-person advising to work out the semester-by-semester courses | ** Declaration of Bioinformatics concentration: In-person advising to work out the semester-by-semester courses | ||
** Approve on department spreadsheet (or send email to "Samantha Sheppard-Lahiji" and "HTR Bio" <biology@hunter.cuny.edu>) | ** Approve on department spreadsheet (or send email to "Samantha Sheppard-Lahiji" and "HTR Bio" <biology@hunter.cuny.edu>) | ||
** Students should take Bioinformatics-specific electives (8 cred; see Hunter Catalog below), not general electives | ** Students should take Bioinformatics-specific electives (8 cred; see Hunter Catalog below), '''not general electives''' | ||
*** Examples: Anthrop302 (3 cr); Chem333 (3 cr); BIOL47119 & BIOL47120 (3cr); BIOL48002 (2 cr) | |||
** Students need to take BIOL48002 (2 cr), which counts towards as research credit, to graduate as honors | ** Students need to take BIOL48002 (2 cr), which counts towards as research credit, to graduate as honors | ||
* General advising: ~40 students every semester. Send out emails to students. Go through student courses by Email or by appointment | * General advising: | ||
** ~40 students every semester. Send out emails to students. Go through student courses by Email or by appointment | |||
** Recommend new math courses: '''MATH15200 & STAT21350''' | |||
* Hosting QuBi students in lab | |||
** This is to enhance the informatics and coding skills of our students | |||
** Students should register and get '''BIOL48002''' credits, which counts towards their elective credits & eligibility for honors | |||
** 3-5 students per semester | |||
* Outside research opportunities | * Outside research opportunities | ||
** MIT Quantitative Workshop (first week of January, in Boston). Coordination with CS (Saad & Susan Epstein) in Fall | ** MIT Quantitative Workshop (first week of January, in Boston). Coordination with CS (Saad & Susan Epstein) in Fall | ||
** Simons Foundation/Flatiron Institute Center for Computational Biology (CCB) Internship program. Open House in Spring | ** Simons Foundation/Flatiron Institute Center for Computational Biology (CCB) Internship program. Open House in Spring | ||
==Course/Lecture syllabi== | |||
* [[Computational Genomics (KIZ, Fall 2024)]] | |||
* [[NYRaMP-Informatics-2024|NYRaMP Workshop (August 2024)]] | |||
* BIOL47120 BioMedical Genomics (Spring 2024). Tutorials: [https://borreliabase.org/~wgqiu/tutorial-markdown.html R Markdown] [https://borreliabase.org/~wgqiu/cluster-analysis.html Cluster analysis] [https://borreliabase.org/~wgqiu/scRNA-analysis.html single-cell RNA-seq] | |||
* BIOL425 Computational Molecular Biology (Spring, 2023). [https://github.com/weigangq/CSB-BIOL425/tree/master/lecture-materials Lecture material on github] | * BIOL425 Computational Molecular Biology (Spring, 2023). [https://github.com/weigangq/CSB-BIOL425/tree/master/lecture-materials Lecture material on github] | ||
* [http://borreliabase.org/~wgqiu/r-demo-2023.html | * BIOL714 Cell Biology: [http://borreliabase.org/~wgqiu/r-demo-2024.html R Demo (Spring 2024)] [http://borreliabase.org/~wgqiu/r-demo-2023.html R Demo (Spring 2023)] | ||
* QuBi module: [[QuBi/module/bio203-lab12—2022|BIOL20300 Molecular Genetics, Lab 12 (2023)]] | * QuBi module: [[QuBi/module/bio203-lab12—2022|BIOL20300 Molecular Genetics, Lab 12 (2023)]] | ||
* QuBi module: [[QuBi/modules/biol203-geno-pheno-association-2022|BIOL20300 Molecular Genetics, Lab 13 (2022)]] | * QuBi module: [[QuBi/modules/biol203-geno-pheno-association-2022|BIOL20300 Molecular Genetics, Lab 13 (2022)]] | ||
* QuBi module: [[QuBi/modules/biol303|BIOL30300 Cell Biology, Bioinformatics Lab (transcriptome analysis)]] | * QuBi module: [[QuBi/modules/biol303|BIOL30300 Cell Biology, Bioinformatics Lab (transcriptome analysis)]] | ||
* [[BigData 2020|Big Data (Summer, 2020)]] | * [[BigData 2020|Big Data (Summer, 2020)]] | ||
* [[BioMed-R-2020|BIOL47120 Biomedical Genomics II (Spring, 2020)]] | * [[BioMed-R-2020|BIOL47120 Biomedical Genomics II (Spring, 2020)]] | ||
** [http://borreliabase.org/~wgqiu/tutorial-markdown.html Tutorial: R Markdown (Spring 2024)] | |||
** [http://borreliabase.org/~wgqiu/cluster-analysis.html Tutorial: Cluster analysis (Spring 2024)] | |||
** [http://borreliabase.org/~wgqiu/scRNA-analysis.html Tutorial: single-cel transcriptome analysis (Spring 2024)] | |||
* [[Biol425 2020|BIOL425 Computational Molecular Biology (Spring, 2020)]] | * [[Biol425 2020|BIOL425 Computational Molecular Biology (Spring, 2020)]] | ||
* [[Biol375 2019|BIOL37500, Molecular Evolution (Fall, 2019)]] | * [[Biol375 2019|BIOL37500, Molecular Evolution (Fall, 2019)]] | ||
Line 161: | Line 182: | ||
==SARS-CoV-2 genome evolution== | ==SARS-CoV-2 genome evolution== | ||
<gallery mode="packed" heights="200px" perrow="3" style="text-align:left"> | <gallery mode="packed" heights="200px" perrow="3" style="text-align:left"> | ||
File:Cov-fig1.jpg | Akther, Bezrucenkovas, Sulkow, Panlasigui, Qiu, Di (April, 2020). "CoV Genome Tracker: tracing genomic footprints of Covid-19 pandemic". '''''[https://www.biorxiv.org/content/biorxiv/early/2020/04/14/2020.04.10.036343.full.pdf BioRxiv]'''''; Web app: SARS-CoV-2 Genome Tracker; Github: https://github.com/weigangq/cov-browser | File:Cov-fig1.jpg | Akther, Bezrucenkovas, Sulkow, Panlasigui, Qiu, Di (April, 2020). "CoV Genome Tracker: tracing genomic footprints of Covid-19 pandemic". '''''[https://www.biorxiv.org/content/biorxiv/early/2020/04/14/2020.04.10.036343.full.pdf BioRxiv]'''''; [https://cov.genometracker.org/ Web app: SARS-CoV-2 Genome Tracker]; Github: https://github.com/weigangq/cov-browser | ||
File:Rec-fig2.png | Akther, Li, Martin, Di, Sulkow, Pante, Bezrucenlovas, Luft, Qiu (May, 2020). "Origin, recombination, and missed opprotunities: a genomic perspective of the first 100 days of COVID-19 pandemic". (Unpublished). | File:Rec-fig2.png | Akther, Li, Martin, Di, Sulkow, Pante, Bezrucenlovas, Luft, Qiu (May, 2020). "Origin, recombination, and missed opprotunities: a genomic perspective of the first 100 days of COVID-19 pandemic". (Unpublished). | ||
File:Cov-fig3-trace.png | Akther, Bezrucenlovas, Li, Sulkow, Di, Pante, Martin, Luft, Qiu (Sep, 2021). "Following the Trail of One Million Genomes: Footprints of SARS-CoV-2 Adaptation to Humans". '''''[https://www.biorxiv.org/content/biorxiv/early/2021/05/10/2021.05.07.443114.full.pdf BioRxiv link]''''': . Github: https://github.com/weigangq/cov-db | File:Cov-fig3-trace.png | Akther, Bezrucenlovas, Li, Sulkow, Di, Pante, Martin, Luft, Qiu (Sep, 2021). "Following the Trail of One Million Genomes: Footprints of SARS-CoV-2 Adaptation to Humans". '''''[https://www.biorxiv.org/content/biorxiv/early/2021/05/10/2021.05.07.443114.full.pdf BioRxiv link]''''': . Github: https://github.com/weigangq/cov-db | ||
Line 167: | Line 188: | ||
==Lab Resources & Protocols== | ==Lab Resources & Protocols== | ||
* [[Monte Carlo Club]] | |||
* [[NY-RaMP Mentoring]] | |||
* Borreliella genome sequencing consortium: Weekly meetings (Tu @11): Since Jan 2023 | * Borreliella genome sequencing consortium: Weekly meetings (Tu @11): Since Jan 2023 | ||
* Borreliella diagnostic antigens (Fall 2023-Fall 2027): | * Borreliella diagnostic antigens (Fall 2023-Fall 2027): | ||
Line 174: | Line 197: | ||
* Qiu lab Github repositories: https://github.com/weigangq/?tab=repositories | * Qiu lab Github repositories: https://github.com/weigangq/?tab=repositories | ||
* [[Mini-Tutorals|Mini-Protocols]] (frequently used computer codes and pipelines) | * [[Mini-Tutorals|Mini-Protocols]] (frequently used computer codes and pipelines) | ||
* T[[Tick protocol|ick handling protocols]] | * T[[Tick protocol|ick handling protocols]] | ||
* [[A Primer on the Cluster System at Hunter|Hunter HPC Usage]] | * [[A Primer on the Cluster System at Hunter|Hunter HPC Usage]] |
Latest revision as of 12:53, 22 September 2024
Weigang Qiu, Ph.D., Professor Department of Biological Sciences Hunter College of City University of New York Belfer Research Building, Room 402 413 East 69th Street, New York, NY 10021 Office: 1-212-896-0445 Email: wqiu-at-(hunter.cuny.edu) |
Fieldwork Gallery
Lab publications
Lyme Genomics, Evolution, & Ecology
Akther et al. 2024. "Natural selection and recombination at host-interacting lipoprotein loci drive genome diversification of Lyme disease and related bacteria" mBio 0:e01749-24. Press coverage: CUNY Graduate Center News Story; Hunter press
Di*, Akther*, Bezrucenkovas, Ivanova, Sulkow, Wu, Mneimneh, Gomes-Solecki, Qiu (2021). "Maximum antigen diversification in a lyme bacterial population and evolutionary strategies to overcome pathogen diversity". The ISME Journal. 16, 447-464. (*co-first authors) Blog Post
Evolution & Learning Algorithms
Informatics Tool Development
last update: March 20, 2023
Lab members and trainees
Year/Period | Doctoral members & trainees | Other members & trainees |
---|---|---|
Current Academic Year
(Fall 2022, Spring 2023 & Summer 2023) |
|
|
Alumni (Since Fall 2002) |
|
(published coauthors)
|
Web Apps
Apps with Collaborators (or from published papers)
Borrelia diagnostic antigens (App developed by Liann Aris-Henry; Data from Arumugam et al (2019))
Borrelia growth transcriptome (App developed by Laziz Asamov; Data from Arnold et al (2016))
Data & GSEA associated with Polotskaia_etal_2014 (with Bargonetti Lab @Hunter)
Qiu Lab Apps
Curricular Development & Bioinformatics/QuBi Advising
- QuBi advisors: Weigang Qiu, Ntino Krampis, Rabindra Mandal (Biology); Saad Mneimeih, Lei Xie (CS); Akira Kawamura (Chem); Dana Sylvan (Math & Stats)
- Permission for non-Biology majors to take BIOL203 & BIOL425, every Spring
- Collect names, major, and IDs to send to course coordinator to grant permission. Waive BIOL10200 pre-reqs for taking BIOL203.
- Curricular resources:
- Biology courses and pre-reqs
- Hunter Biology Major 1 (including the Bioinformatics Option)
- Hunter Chemistry Major 2 (including the Bioinformatics Option)
- Hunter Computer Science (including Bioinformatics Concentration)
- Hunter Mathematics (including the Quantitative Biology Concentration)
- Hunter Statistics (including the Quantitative Biology Concentration)
- QuBi advising:
- Declaration of Bioinformatics concentration: In-person advising to work out the semester-by-semester courses
- Approve on department spreadsheet (or send email to "Samantha Sheppard-Lahiji" and "HTR Bio" <biology@hunter.cuny.edu>)
- Students should take Bioinformatics-specific electives (8 cred; see Hunter Catalog below), not general electives
- Examples: Anthrop302 (3 cr); Chem333 (3 cr); BIOL47119 & BIOL47120 (3cr); BIOL48002 (2 cr)
- Students need to take BIOL48002 (2 cr), which counts towards as research credit, to graduate as honors
- General advising:
- ~40 students every semester. Send out emails to students. Go through student courses by Email or by appointment
- Recommend new math courses: MATH15200 & STAT21350
- Hosting QuBi students in lab
- This is to enhance the informatics and coding skills of our students
- Students should register and get BIOL48002 credits, which counts towards their elective credits & eligibility for honors
- 3-5 students per semester
- Outside research opportunities
- MIT Quantitative Workshop (first week of January, in Boston). Coordination with CS (Saad & Susan Epstein) in Fall
- Simons Foundation/Flatiron Institute Center for Computational Biology (CCB) Internship program. Open House in Spring
Course/Lecture syllabi
- Computational Genomics (KIZ, Fall 2024)
- NYRaMP Workshop (August 2024)
- BIOL47120 BioMedical Genomics (Spring 2024). Tutorials: R Markdown Cluster analysis single-cell RNA-seq
- BIOL425 Computational Molecular Biology (Spring, 2023). Lecture material on github
- BIOL714 Cell Biology: R Demo (Spring 2024) R Demo (Spring 2023)
- QuBi module: BIOL20300 Molecular Genetics, Lab 12 (2023)
- QuBi module: BIOL20300 Molecular Genetics, Lab 13 (2022)
- QuBi module: BIOL30300 Cell Biology, Bioinformatics Lab (transcriptome analysis)
- Big Data (Summer, 2020)
- BIOL47120 Biomedical Genomics II (Spring, 2020)
- BIOL425 Computational Molecular Biology (Spring, 2020)
- BIOL37500, Molecular Evolution (Fall, 2019)
- Southwest University R course (Summer, 2019)
- Analysis of Biological Data (Spring, 2017)
- Bioinformatics Workshop (Summer, 2014)
SARS-CoV-2 genome evolution
Akther, Bezrucenkovas, Sulkow, Panlasigui, Qiu, Di (April, 2020). "CoV Genome Tracker: tracing genomic footprints of Covid-19 pandemic". BioRxiv; Web app: SARS-CoV-2 Genome Tracker; Github: https://github.com/weigangq/cov-browser
Akther, Bezrucenlovas, Li, Sulkow, Di, Pante, Martin, Luft, Qiu (Sep, 2021). "Following the Trail of One Million Genomes: Footprints of SARS-CoV-2 Adaptation to Humans". BioRxiv link: . Github: https://github.com/weigangq/cov-db
Lab Resources & Protocols
- Monte Carlo Club
- NY-RaMP Mentoring
- Borreliella genome sequencing consortium: Weekly meetings (Tu @11): Since Jan 2023
- Borreliella diagnostic antigens (Fall 2023-Fall 2027):
- Zoom call (Jan 23, 2024)
- Next meeting: March 23, 2024
- Qiu lab network first-time user guide
- Qiu lab Github repositories: https://github.com/weigangq/?tab=repositories
- Mini-Protocols (frequently used computer codes and pipelines)
- Tick handling protocols
- Hunter HPC Usage
- R for Data Science (2e), (2024) by Wickham, Grolemund & Çetinkaya-Rundel (Bookdown version)
Wiki Help
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